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Christian Beyer Selected Research

Bleomycin (Blenoxane)

1/2018Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.
6/2017Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages.
1/2017Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling.
5/2016Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis.
3/2016Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis.
9/2015S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.
6/2015Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
5/2015Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
3/2015Vitamin D receptor regulates TGF-β signalling in systemic sclerosis.
11/2014The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor β and contributes to the development of experimental dermal fibrosis.
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Christian Beyer Research Topics

Disease

43Fibrosis (Cirrhosis)
01/2020 - 01/2010
22Systemic Scleroderma (Systemic Sclerosis)
01/2020 - 01/2010
6Bronchiolitis Obliterans Syndrome
06/2017 - 01/2010
3Inflammation (Inflammations)
01/2020 - 03/2011
3Idiopathic Pulmonary Fibrosis
11/2017 - 07/2013
3Osteoarthritis
01/2017 - 03/2015
3Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
10/2016 - 11/2008
3Neoplasms (Cancer)
09/2015 - 05/2011
3Vascular Diseases (Vascular Disease)
07/2013 - 01/2009
2Arthritis (Polyarthritis)
01/2019 - 08/2010
2Pulmonary Arterial Hypertension
11/2017 - 06/2012
2Osteophyte
11/2016 - 07/2013
2Disease Progression
05/2016 - 07/2013
2Churg-Strauss Syndrome (Allergic Angiitis)
11/2013 - 03/2012
2Necrosis
08/2013 - 10/2012
2Brain Ischemia (Cerebral Ischemia)
08/2012 - 11/2008
1Melanoma (Melanoma, Malignant)
01/2021
1Microvascular Rarefaction
11/2017
1Interstitial Lung Diseases (Interstitial Lung Disease)
11/2017
1Psoriatic Arthritis
06/2017
1Psoriasis (Pustulosis Palmaris et Plantaris)
06/2017
1Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2017
1Hypertrophy
11/2016
1Bone Resorption
01/2016
1Neoplasm Metastasis (Metastasis)
09/2015
1Graft vs Host Disease (Graft-Versus-Host Disease)
06/2015
1Carcinogenesis
05/2015
1Knee Osteoarthritis
03/2015
1Hip Osteoarthritis (Coxarthrosis)
03/2015

Drug/Important Bio-Agent (IBA)

28Bleomycin (Blenoxane)FDA LinkGeneric
01/2018 - 03/2011
12CollagenIBA
11/2016 - 07/2011
9indium-bleomycinIBA
06/2017 - 12/2011
9Transforming Growth Factors (Transforming Growth Factor)IBA
01/2017 - 05/2012
8Hydroxyproline (4 Hydroxyproline)IBA
09/2015 - 03/2011
4Soluble Guanylyl CyclaseIBA
01/2018 - 06/2012
4Proteins (Proteins, Gene)FDA Link
01/2017 - 01/2009
3Tyrosine (L-Tyrosine)FDA Link
01/2018 - 07/2013
3Messenger RNA (mRNA)IBA
11/2016 - 07/2013
3CateninsIBA
03/2014 - 05/2012
3Small Interfering RNA (siRNA)IBA
03/2014 - 05/2012
2Monoclonal AntibodiesIBA
01/2021 - 07/2013
2EnzymesIBA
01/2019 - 05/2011
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
11/2017 - 01/2009
2Phosphotransferases (Kinase)IBA
11/2017 - 07/2013
2nintedanibIBA
11/2017 - 05/2016
2Interleukin-6 (Interleukin 6)IBA
06/2017 - 06/2015
2Biomarkers (Surrogate Marker)IBA
01/2017 - 01/2010
2LigandsIBA
11/2016 - 03/2014
2Vasodilator Agents (Vasodilators)IBA
10/2016 - 08/2012
2Tyrosine Kinase InhibitorsIBA
05/2016 - 01/2010
2Cathepsin KIBA
01/2016 - 08/2010
2DNA (Deoxyribonucleic Acid)IBA
06/2014 - 10/2012
2HMGB1 Protein (HMG1)IBA
08/2013 - 10/2012
2Ethanol (Ethyl Alcohol)IBA
08/2013 - 10/2012
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
08/2013 - 10/2012
2Imatinib Mesylate (Gleevec)FDA Link
07/2013 - 01/2010
2Histones (Histone)IBA
04/2013 - 10/2012
1IpilimumabIBA
01/2021
1Immune Checkpoint InhibitorsIBA
01/2021
1Lysophosphatidic Acid ReceptorsIBA
01/2020
1lysophosphatidic acidIBA
01/2020
1Metalloproteases (Metalloproteinases)IBA
01/2019
1Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
01/2018
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
11/2017
1Phenobarbital (Luminal)FDA Link
11/2017
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
11/2017
1Fos-Related Antigen-2IBA
11/2017
1Type I DNA Topoisomerases (Topoisomerase I)IBA
06/2017
1apremilastIBA
06/2017
1Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
06/2017
1RolipramIBA
06/2017
1GNF6231IBA
01/2017
1safranine T (safranin)IBA
11/2016
1OsteocalcinIBA
11/2016
1Activating Transcription Factor 3IBA
03/2016
1Tartrate-Resistant Acid PhosphataseIBA
01/2016
1Urokinase Plasminogen Activator ReceptorsIBA
10/2015
1Calcium-Binding ProteinsIBA
09/2015
1riociguatIBA
08/2015
1Sildenafil Citrate (Viagra)FDA Link
08/2015
1Guanosine Monophosphate (5' Guanylic Acid)IBA
08/2015
1Pharmaceutical PreparationsIBA
08/2015
1Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
08/2015
1Liver X ReceptorsIBA
06/2015
1T0901317IBA
06/2015
1Casein Kinase II (Casein Kinase 2)IBA
05/2015
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
05/2015
1Calcitriol Receptors (Calcitriol Receptor)IBA
03/2015
1MicroRNAs (MicroRNA)IBA
03/2015
1Cholecalciferol (Vitamin D3)FDA Link
03/2015
1paricalcitol (Zemplar)FDA Link
03/2015
1Member 1 Group A Nuclear Receptor Subfamily 4IBA
02/2015
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
11/2014
1Constitutive Androstane ReceptorIBA
11/2014
1Orphan Nuclear ReceptorsIBA
11/2014
1MethyltransferasesIBA
06/2014
1DecitabineFDA Link
06/2014

Therapy/Procedure

9Therapeutics
10/2016 - 01/2010
1Bone Plates (Bone Plate)
11/2016
1Arthroplasty
03/2015